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2-Bromophenetole and triphenylphosphorus as novel phosphonioethylation precursors. Vinylphosphonium and 2-aminovinylphosphonium salts-preparation and applications in organic synthesis. The Wittig and related reactions in natural product synthesis. Stereochemistry, mechanism, and selected synthetic aspects. The Wittig olefination reaction and modifications involving phosphoryl-stabilized carbanions.

Nobel Lecture: from Diyls to My Idyll (1979). The most common functional groups in bioactive molecules and how their popularity has evolved over time. Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes. Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement.

Applications of visible light photoredox catalysis to the synthesis of natural products and related compounds. Forging C( sp 3)–C( sp 3) bonds with carbon-centered radicals in the synthesis of complex molecules. Photoredox catalysis in organic chemistry. Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Visible-light photoredox decarboxylative couplings. Metallaphotoredox-catalysed sp 3– sp 3 cross-coupling of carboxylic acids with alkyl halides. Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acids with vinyl halides. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp 3-carbons with aryl halides. Practical Ni-catalyzed aryl–alkyl cross-coupling of secondary redox-active esters. A general alkyl–alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents. Decarboxylative reactions with and without light-a comparison. Metal-Catalyzed Cross-Coupling Reactions 2nd edn (Wiley, 2004). Target-oriented and diversity-oriented organic synthesis in drug discovery.

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